The incidents happened near the intersection of Faudree Road and Dorado Drive around 4:30 PM Wednesday.
Witnesses tell Big 2 that two cars got into a minor accident at the intersection.
Another vehicle also reportedly stopped in the area, so the driver could help out the people in that crash.
However, another driver didn't see the stopped vehicles, and that driver's vehicle reportedly barreled into them.
Witnesses say the driver who caused the second, more serious crash was using their phone while driving.
"I mean, I ride a bike every day around the Midland-Odessa area, and it scares me because of stuff like this -- people texting and driving and talking on their phone," a witness -- who did not want his name released -- told Big 2. "Just like earlier when they started directing traffic again, there were people on the phone, driving through where the police officers are directing traffic. You know, people don't care around here. They need to start paying attention."
At least 2 people were rushed to Medical Center Hospital with unknown injuries after the crash.
Odessa Police, Fire and Rescue units and E.M.S. units responded to the wreck.
Police haven't said if anyone will get a citation for the crash.