The wreckage stretched from at least Exit 17 to Exit 16.
It happened in near zero visibility around 12:45pm.
Initial reports say 'multiple cars' are involved, including at least one semi-truck that crashed into a car.
Rescue crews have no idea how many cars or people are involved in the wreck because they are having trouble locating the vehicles.
Crews called in the 'mass-casualty' bus to take more than a dozen injured victims to the hospital.
Initial reports say ten people were taken to UMC and seven to Covenant with moderate injuries.
Radio traffic reported some victims were calling 911 from their cars in order to get help.
Emergency workers also had a hard time getting to the wreckage, setting up a central triage point for victims instead.
Officers from DPS, Lubbock County Sheriff's Office and New Deal are responding.
Fire and emergency crews from New Deal, Abernathy and Idalou are also en route.
The pile-up shut has down I-27 in both directions from Exit 13 to Exit 17.