TXDOT crews are expected to start working this week on a 16.7 mile stretch of TX 349 between the Midland County line and the road's intersection with TX 176 in Martin County.
The project will expand the highway from a 2-lane road to a 4-lane divided highway.
TXDOT officials say that the work will be done in 3-mile sections.
The speed limit in the work zones will be dropped to 60 miles per hour, and vehicle width will be restricted to 10 feet in order to improve safety.
The southern portion of the project should be complete in late summer 2014.
Another 9.5 mile portion of the expansion project is already underway north of the TX 176 intersection.
That portion of the roadway should be fully upgraded by this summer.
A 6.5 mile portion of the roadway between the Dawson County line and the portion that's already under construction will also be upgraded at a date to be determined.
Finally, the Lubbock district of TXDOT will take bids on an expansion of the remaining 17 miles of TX 349 between the Dawson County line and Lamesa.
Once the entire project is finished, TX 349 will be a 4-lane divided highway from Midland to Lamesa.