The Afghan leader's visit to the White House on Friday marks his second such meeting with the President.
Karzai's visit comes as the withdrawal of U-S and NATO troops approaches.
By the end of the year, troops are expected to hand over the responsibility of the country's security.
A December review showed that the capability of the Afghan military and police continue to lag behind expectations.
Karzai is also expected to step down in 2014, when elections are held.